Dihydro Donepezil

Names

[ CAS No. ]:
120012-04-6

[ Name ]:
Dihydro Donepezil

[Synonym ]:
IND032
Dihydro Donepezil
Donepezil Impurity 5

Biological Activity

[Description]:

Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.

Chemical & Physical Properties

[ Boiling Point ]:
520.367ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₁NO₃

[ Molecular Weight ]:
381.50800

[ Flash Point ]:
268.509ºC

[ Exact Mass ]:
381.23000

[ PSA ]:
41.93000

[ LogP ]:
4.14970

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.587

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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