120012-04-6

120012-04-6 structure

Name: Dihydro Donepezil
Chemical Name: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol
CAS Number: 120012-04-6
Molecular Formula: C₂₄H₃₁NO₃
Molecular Weight: 381.50800
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2018-12-27 21:21:07
Modify Date: 2024-01-01 20:32:17
Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].

Name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol
Synonyms	IND032 Dihydro Donepezil Donepezil Impurity 5

Description	Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.

120014-06-4

~68%

120012-04-6

Precursor 1
120014-06-4
DownStream 0