Edrophonium chloride

Names

[ CAS No. ]:
116-38-1

[ Name ]:
Edrophonium chloride

[Synonym ]:
edrophonium chloride
MFCD00055064
EINECS 204-138-4
Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (1:1)
N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium chloride
Ethyl(m-hydroxyphenyl)dimethylammonium chloride
Tensilon
N-Ethyl-3-hydroxy-N,N-dimethylanilinium chloride
ethyl-(3-hydroxyphenyl)-dimethylazanium,chloride
Edrophonium (chloride)

Biological Activity

[Description]:

Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> AChE

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.395 g/mL at 25 °C(lit.)

[ Boiling Point ]:
130 °C20 mm Hg(lit.)

[ Melting Point ]:
162-163°C

[ Molecular Formula ]:
C₁₀H₁₆ClNO

[ Molecular Weight ]:
201.693

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
201.092041

[ PSA ]:
20.23000

[ Index of Refraction ]:
n20/D 1.486(lit.)

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
reacts

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BQ5870000

CHEMICAL NAME :: Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, chloride

CAS REGISTRY NUMBER :: 116-38-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H16-N-O.Cl

MOLECULAR WEIGHT :: 201.72

WISWESSER LINE NOTATION :: QR CK2&1&1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,327,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,121,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,185,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5548 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8250 (estimated) No. of Female Employees: 7491 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BQ5870000

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%