7-Ethoxy-4-(trifluoromethyl)coumarin

Names

[ Name ]:
7-Ethoxy-4-(trifluoromethyl)coumarin

[Synonym ]:
2H-1-Benzopyran-2-one,7-ethoxy-4-(trifluoromethyl)
7-Ethoxy-4-(trifluoromethyl)coumarin
Ethyl 4-(trifluoromethyl)umbelliferyl ether
7-Ethoxy-4-trifluoromethylcoumarin
Etfc cpd

Biological Activity

[Description]:

7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily[1]

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Morse MA, et al. High-performance liquid chromatographic method for measurement of cytochrome P450-mediated metabolism of 7-ethoxy-4-trifluoromethylcoumarin. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):290-3.

Chemical & Physical Properties

[ Density]:
1.368 g/cm3

[ Boiling Point ]:
303.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₉F₃O₃

[ Molecular Weight ]:
258.19300

[ Flash Point ]:
132.7ºC

[ Exact Mass ]:
258.05000

[ PSA ]:
39.44000

[ LogP ]:
3.21050

[ Vapour Pressure ]:
0.000952mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.

Arch. Pharm. Res. 38 , 691-704, (2015)

Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in ...

Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.

Toxicol. Appl. Pharmacol. 289 , 223-30, (2015)

Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...

Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.

Biochem. Pharmacol. 95 , 126-32, (2015)

Combustion processes generate particulate matter (PM) that can affect human health. The presence of redox-active metals and aromatic hydrocarbons in the post-combustion regions results in the formatio...