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7-Methoxy-4-(trifluoromethyl)coumarin

Names

[ CAS No. ]:
575-04-2

[ Name ]:
7-Methoxy-4-(trifluoromethyl)coumarin

[Synonym ]:
7-methoxy-4-(trifluoromethyl)chromen-2-one

Chemical & Physical Properties

[ Density]:
1.418g/cm3

[ Boiling Point ]:
287.4ºC at 760 mmHg

[ Molecular Formula ]:
C11H7F3O3

[ Molecular Weight ]:
244.16700

[ Flash Point ]:
123.6ºC

[ Exact Mass ]:
244.03500

[ PSA ]:
39.44000

[ LogP ]:
2.82040

[ Index of Refraction ]:
1.506

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Synthetic Route

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Identification and functional characterization of novel feline cytochrome P450 2A.

Xenobiotica 45 , 503-10, (2015)

1. Cytochrome P450s are the major metabolizing enzymes for xenobiotics in humans and other mammals. Although the domestic cat Felis catus, an obligate carnivore, is the most common companion animal, t...

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.

Expert Opin. Drug Metab. Toxicol. 10(10) , 1313-24, (2014)

Drug resistance by Plasmodium falciparum remains a challenge in malaria chemotherapy. This paper will focus on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hy...

Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.

Xenobiotica 44(7) , 615-26, (2014)

1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of sever...


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Related Compounds