7-Hydroxy-4-(trifluoromethyl)coumarin

Names

[ CAS No. ]:
575-03-1

[ Name ]:
7-Hydroxy-4-(trifluoromethyl)coumarin

[Synonym ]:
7-Hydroxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one
7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
7-hydroxy-4-(trifluoromethyl)chromen-2-one
2H-1-Benzopyran-2-one, 7-hydroxy-4-(trifluoromethyl)-
MFCD00037578

Biological Activity

[Description]:

4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Others

[References]

[1]. Renwick AB, et, al. Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica. 2001 Dec;31(12):861-78.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
311.4±42.0 °C at 760 mmHg

[ Melting Point ]:
178-180 °C(lit.)

[ Molecular Formula ]:
C₁₀H₅F₃O₃

[ Molecular Weight ]:
230.140

[ Flash Point ]:
142.2±27.9 °C

[ Exact Mass ]:
230.019073

[ PSA ]:
50.44000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Water Solubility ]:
DMF: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H315-H319-H335

[ Precautionary Statements ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S36-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...