7-Benzyloxy-4-(trifluoromethyl)coumarin

Names

[ CAS No. ]:
220001-53-6

[ Name ]:
7-Benzyloxy-4-(trifluoromethyl)coumarin

[Synonym ]:
7-benzyloxy-trifluoromethyl coumarin
7-Benzyloxy-4-trifluoromethylcoumarin

Biological Activity

[Description]:

7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Others

[References]

[1]. A B Renwick, et al. Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms. Xenobiotica. 2000 Oct;30(10):955-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₁F₃O₃

[ Molecular Weight ]:
320.26300

[ Exact Mass ]:
320.06600

[ PSA ]:
39.44000

[ LogP ]:
4.39080

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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