5-(Biotinamido)pentylamine

Names

[ CAS No. ]:
115416-38-1

[ Name ]:
5-(Biotinamido)pentylamine

[Synonym ]:
Biotinyl cadaverine
Cadaverine-X-biotin
Biotincadaverine

Biological Activity

[Description]:

5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.131g/cm3

[ Boiling Point ]:
652ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₂₈N₄O₂S

[ Molecular Weight ]:
328.47300

[ Flash Point ]:
348.1ºC

[ Exact Mass ]:
328.19300

[ PSA ]:
128.53000

[ LogP ]:
2.46680

[ Vapour Pressure ]:
7.01E-17mmHg at 25°C

[ Index of Refraction ]:
1.529

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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