115416-38-1

115416-38-1 structure

Name: 5-(Biotinamido)pentylamine
Chemical Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(5-aminopentyl)pentanamide
CAS Number: 115416-38-1
Molecular Formula: C₁₅H₂₈N₄O₂S
Molecular Weight: 328.47300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-03-23 08:00:00
Modify Date: 2025-08-25 19:38:19
5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(5-aminopentyl)pentanamide
Synonyms	Biotinyl cadaverine Cadaverine-X-biotin Biotincadaverine

Description	5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

328273-17-2

~91%

115416-38-1

Literature: ASTRAZENECA AB; UNIVERSITY OF CHICAGO Patent: WO2006/65218 A1, 2006 ; Location in patent: Page/Page column 16 ; WO 2006/065218 A1

148759-41-5

58-85-5

~92%

115416-38-1

51644-96-3

115416-38-1

Literature: Tetrahedron, , vol. 56, # 46 p. 9003 - 9014

58-85-5

115416-38-1

Literature: Tetrahedron, , vol. 56, # 46 p. 9003 - 9014

111-24-0

115416-38-1

Literature: Angewandte Chemie - International Edition, , vol. 52, # 1 p. 366 - 370

17607-21-5

115416-38-1

Literature: Angewandte Chemie - International Edition, , vol. 52, # 1 p. 366 - 370