5-(Biotinamido)pentylamine
Modify Date: 2024-01-13 13:12:13
5-(Biotinamido)pentylamine structure
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Common Name | 5-(Biotinamido)pentylamine | ||
|---|---|---|---|---|
| CAS Number | 115416-38-1 | Molecular Weight | 328.47300 | |
| Density | 1.131g/cm3 | Boiling Point | 652ºC at 760mmHg | |
| Molecular Formula | C15H28N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 348.1ºC | |
Use of 5-(Biotinamido)pentylamine5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(5-aminopentyl)pentanamide |
|---|---|
| Synonym | More Synonyms |
| Description | 5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.131g/cm3 |
|---|---|
| Boiling Point | 652ºC at 760mmHg |
| Molecular Formula | C15H28N4O2S |
| Molecular Weight | 328.47300 |
| Flash Point | 348.1ºC |
| Exact Mass | 328.19300 |
| PSA | 128.53000 |
| LogP | 2.46680 |
| Vapour Pressure | 7.01E-17mmHg at 25°C |
| Index of Refraction | 1.529 |
| Storage condition | -20°C |
|
~91%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: ASTRAZENECA AB; UNIVERSITY OF CHICAGO Patent: WO2006/65218 A1, 2006 ; Location in patent: Page/Page column 16 ; WO 2006/065218 A1 |
|
~92%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: Cheng, Ting-Jen R.; Wang, Shi-Yun; Wen, Wen-Hsien; Su, Ching-Yao; Lin, Mengi; Wen-I Huang; Liu, Ming-Tsan; Wu, Ho-Sheng; Wang, Nung-Sen; Cheng, Chung-Kai; Chen, Chun-Lin; Ren, Chien-Tai; Wu, Chung-Yi; Fang, Jim-Min; Cheng, Yih-Shyun E.; Wong, Chi-Huey Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 366 - 370 |
|
~%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: Tetrahedron, , vol. 56, # 46 p. 9003 - 9014 |
|
~%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: Tetrahedron, , vol. 56, # 46 p. 9003 - 9014 |
|
~%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: Angewandte Chemie - International Edition, , vol. 52, # 1 p. 366 - 370 |
|
~%
5-(Biotinamido)... CAS#:115416-38-1 |
| Literature: Angewandte Chemie - International Edition, , vol. 52, # 1 p. 366 - 370 |
![tert-butyl (5-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)pentyl)carbamate structure](https://www.chemsrc.com/caspic/363/328273-17-2.png)
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