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DHODH-IN-4

Names

[ CAS No. ]:
1148125-93-2

[ Name ]:
DHODH-IN-4

Biological Activity

[Description]:

DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Research Areas >> Inflammation/Immunology

[Target]

IC50: 4 μM (PfDHODH), 0.18 μM (HsDHODH)[1].


[References]

[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H12Cl2N2O2

[ Molecular Weight ]:
347.20

Related Compounds