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DHODH-IN-20

Names

[ CAS No. ]:
2639835-02-0

[ Name ]:
DHODH-IN-20

Biological Activity

[Description]:

DHODH-IN-20 (Compound 133) is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Inflammation/Immunology

[References]

[1]. Sabnis RW. Biaryl Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML). ACS Med Chem Lett. 2022;13(2):158-159.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25F4N3O3

[ Molecular Weight ]:
479.47

Related Compounds