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1-Acetyl-2-phenylhydrazine

Names

[ CAS No. ]:
114-83-0

[ Name ]:
1-Acetyl-2-phenylhydrazine

[Synonym ]:
EINECS 204-055-3
N'-phenylacetohydrazide
1-Acetyl-2-Phenylhydrazine
MFCD00008672

Biological Activity

[Description]:

N'-Phenylacetohydrazide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
1.143g/cm3

[ Boiling Point ]:
214.1ºC at 760mmHg

[ Melting Point ]:
128-131 °C(lit.)

[ Molecular Formula ]:
C8H10N2O

[ Molecular Weight ]:
150.17800

[ Exact Mass ]:
150.07900

[ PSA ]:
41.13000

[ LogP ]:
1.61350

[ Vapour Pressure ]:
1E-06mmHg at 25°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AJ2900000
CHEMICAL NAME :
Acetic acid, 2-phenylhydrazide
CAS REGISTRY NUMBER :
114-83-0
BEILSTEIN REFERENCE NO. :
0742880
LAST UPDATED :
199706
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C8-H10-N2-O
MOLECULAR WEIGHT :
150.20
WISWESSER LINE NOTATION :
1VMMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 mg/kg/7D-I
TOXIC EFFECTS :
Blood - other changes Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
112 mg/kg/4W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
28 mg/kg/7D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31 gm/kg/79W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
333 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83705 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83705 No. of Facilities: 613 (estimated) No. of Industries: 20 No. of Occupations: 19 No. of Employees: 15429 (estimated) No. of Female Employees: 4988 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H319-H335

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R43

[ Safety Phrases ]:
S22-S26-S36-S24/25

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
AJ2900000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29280090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 29280090

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