1-Phenylpropane-1,2-dione

Names

[ CAS No. ]:
579-07-7

[ Name ]:
1-Phenylpropane-1,2-dione

[Synonym ]:
1-phenylpropane-1,2-dione
MFCD00008755
EINECS 209-435-2
1-Phenyl-1,2-propanedione
1,2-Propanedione, 1-phenyl-
1-phenyl-1,2-propandione

Biological Activity

[Description]:

1-Phenylpropane-1,2-dione, isolated from young Ephedra sinica Stapf (Ephedraceae), is biosynthetic precursors of the ephedrine alkaloids[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

The main active principles of E. sinica are the unique and taxonomically restricted adrenergic agonists phenylpropylamino alkaloids, also known as the ephedrine alkaloids[1].

[References]

[1]. Raz Krizevski, et al. Composition and Stereochemistry of Ephedrine Alkaloids Accumulation in Ephedra Sinica Stapf. Phytochemistry. 2010 Jun;71(8-9):895-903.

[2]. Raz Krizevski, et al. Benzaldehyde Is a Precursor of Phenylpropylamino Alkaloids as Revealed by Targeted Metabolic Profiling and Comparative Biochemical Analyses in Ephedra Spp. Phytochemistry. 2012 Sep;81:71-9.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
228.0±9.0 °C at 760 mmHg

[ Melting Point ]:
<20ºC

[ Molecular Formula ]:
C₉H₈O₂

[ Molecular Weight ]:
148.159

[ Flash Point ]:
84.4±0.0 °C

[ Exact Mass ]:
148.052429

[ PSA ]:
34.14000

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.520

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

J. Med. Chem. 48 , 2906-15, (2005)

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...

Influence of composition on rate of polymerization contraction of light-curing resin composites.

Acta Odontol. Scand. 60(3) , 146-50, (2002)

A slow contraction may result in reduced gap formation when a restorative resin polymerizes in a dental cavity. It was the aim in the present work to investigate the rate of contraction in relation to...

Inhibition of the reconstituted mitochondrial oxoglutarate carrier by arginine-specific reagents.

Arch. Biochem. Biophys. 331(1) , 48-54, (1996)

The effect of arginine-specific reagents on the function of the purified and reconstituted oxoglutarate carrier protein of the inner mitochondrial membrane has been investigated. The alpha-dicarbonyl ...