butane-2,3-dione
Names
[ CAS No. ]:
431-03-8
[ Name ]:
butane-2,3-dione
[Synonym ]:
butanedione
MFCD00008756
2,3-Butanedione
Butan-2,3-dione
EINECS 207-069-8
2,3-butandione
2,3-Butadione
Butane-2,3-dione
Biacetyl
Dimethylglyoxal
2,3-Diketobutane
Diacetyl
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
88.0±0.0 °C at 760 mmHg
[ Melting Point ]:
-4--2 °C
[ Molecular Formula ]:
C4H6O2
[ Molecular Weight ]:
86.089
[ Flash Point ]:
7.2±0.0 °C
[ Exact Mass ]:
86.036781
[ PSA ]:
34.14000
[ LogP ]:
-1.33
[ Vapour density ]:
3 (vs air)
[ Vapour Pressure ]:
62.3±0.1 mmHg at 25°C
[ Index of Refraction ]:
1.381
[ Stability ]:
Stable. Flammable. Incompatible with acids, strong bases, metals, reducing agents, oxidizing agents. Protect from moisture and water. Note low flashpoint.
[ Water Solubility ]:
200 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EK2625000
- CHEMICAL NAME :
- 2,3-Butanedione
- CAS REGISTRY NUMBER :
- 431-03-8
- BEILSTEIN REFERENCE NO. :
- 0605398
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C4-H6-O2
- MOLECULAR WEIGHT :
- 86.10
- WISWESSER LINE NOTATION :
- 1VV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1580 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Vascular - regional or general arteriolar or venous dilation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 990 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48600 mg/kg/90D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - pigmented or nucleated red blood cells
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/kg
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 76,809,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84595 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1503 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84595 No. of Facilities: 185 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 3438 (estimated) No. of Female Employees: 1628 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302-H315-H318-H331-H335
[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;Heavyweight Gloves;multi-purpose combination respirator cartridge (US);Safety Clothing;type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R20/21/22;R36/38
[ Safety Phrases ]:
S9-S16-S26-S37/39-S36/37/39-S39
[ RIDADR ]:
UN 2346 3/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
EK2625000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2914190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914190090
[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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