N,N-Bis(carboxymethyl)-L-lysine

Names

[ Name ]:
N,N-Bis(carboxymethyl)-L-lysine

[Synonym ]:
BIS-BOC-L-CYSTINE
MFCD00237437
BOC-L-CYSTINE extrapure
N,N-Bis(carboxymethyl)-L-lysine
N N-BOC-L-CYSTEINE
L-Lysine, N,N-bis(carboxymethyl)-
N,N'-di-Boc-cystine
N,N'-Bis-Boc-cystine
BOC-L-CYSTINE
N,N-di-Boc-L-cystine

Biological Activity

[Description]:

Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Pydi SP, et al. Amino acid derivatives as bitter taste receptor (T2R) blockers. J Biol Chem. 2014;289(36):25054-25066.

[2]. Sidhu C, et al. Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem. 2017;426(1-2):129-136.

[3]. Masamoto M, et al. Yoshida R. Effects of bitter receptor antagonists on behavioral lick responses of mice. Neurosci Lett. 2020;730:135041.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
537.8±50.0 °C at 760 mmHg

[ Melting Point ]:
>208°C

[ Molecular Formula ]:
C₁₀H₁₈N₂O₆

[ Molecular Weight ]:
262.26

[ Flash Point ]:
279.0±30.1 °C

[ Exact Mass ]:
262.116486

[ PSA ]:
141.16000

[ LogP ]:
-1.77

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ Stability ]:
Moisture Sensitive

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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