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Impurity F of Calcipotriol

Names

[ CAS No. ]:
112875-61-3

[ Name ]:
Impurity F of Calcipotriol

[Synonym ]:
1,3-Bis-O-(tert-butyldimethylsilyl)calcipotriene
(1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
1(S),3(R)-bis(tert-butyl-dimethylsilyloxy)-20(R)-(3'-cyclopropyl-3(S)'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
UNII-4SP93VP62P
Impurity F of Calcipotriol

Biological Activity

[Description]:

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target:Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR
Research Areas >> Cancer

[References]

[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

[2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

[3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

[4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895


[Related Small Molecules]

Calcipotriene | Maxacalcitol | Paricalcitol | Vitamin D3 | 25-Hydroxycalciferol | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | Secalciferol | Seocalcitol | 25,26-Dihydroxyvitamin D3 | Calcitetrol | Eldecalcitol | Ergocalciferol | Vitamin D4 | 24, 25-Dihydroxy VD2 | Calcipotriol Impurity C

Chemical & Physical Properties

[ Molecular Formula ]:
C39H68O3Si2

[ Molecular Weight ]:
641.12600

[ Exact Mass ]:
640.47100

[ PSA ]:
38.69000

[ LogP ]:
11.14960

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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