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Dalfopristin

Names

[ CAS No. ]:
112362-50-2

[ Name ]:
Dalfopristin

Biological Activity

[Description]:

Dalfopristin is a semi-synthetic streptogramin antibiotic. Quinupristin/Dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[Target]

Antibacterial[1]


[In Vitro]

Quinupristin/Dalfopristin(Q/D) is a combination of streptogramins B (Quinupristin) and streptogramins A (Dalfopristin) at 30:70 ratio[1]. Quinupristin/Dalfopristin, a semisynthetic injectable streptogramin, is a combination of 2 synergistic antibiotic components that are derived from pristinamycin: a type B streptogramin (Quinupristin) and a type A streptogramin (Dalfopristin), in a 30:70 weight-to-weight ratio[2].

[References]

[1]. Wang S, et al. Characteristic of Enterococcus faecium clinical isolates with quinupristin/Dalfopristin resistance in China. BMC Microbiol. 2016 Oct 21;16(1):246.

[2]. Sacar M, et al. Comparison of antimicrobial agents as therapy for experimental endocarditis: caused by methicillin-resistant Staphylococcus aureus. Tex Heart Inst J. 2010;37(4):400-4.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
940.5ºC at 760 mmHg

[ Molecular Formula ]:
C34H50N4O9S

[ Molecular Weight ]:
690.84700

[ Flash Point ]:
522.6ºC

[ Exact Mass ]:
690.33000

[ PSA ]:
184.80000

[ LogP ]:
3.61680

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
2-8℃


Related Compounds

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