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BRL 52537 HYDROCHLORIDE

Names

[ CAS No. ]:
112282-24-3

[ Name ]:
BRL 52537 HYDROCHLORIDE

[Synonym ]:
(±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Ethanone, 2-(3,4-dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]-, hydrochloride (1:1)
2-(3,4-Dichlorophenyl)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone hydrochloride (1:1)
2-(3,4-Dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]ethanone hydrochloride (1:1)

Biological Activity

[Description]:

BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 0.24 nM (κ-Opioid receptor) and 1560 nM (μ-Opioid receptor)[1]


[References]

[1]. Toru Goyagi, et al. Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke. 2003 Jun;34(6):1533-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H25Cl3N2O

[ Molecular Weight ]:
391.76

[ Exact Mass ]:
390.103241

[ PSA ]:
23.55000

[ LogP ]:
4.69060

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds