Butanediamide
Names
[ CAS No. ]:
110-14-5
[ Name ]:
Butanediamide
[Synonym ]:
butanediamide
Succinamide
MFCD00008042
EINECS 203-739-9
Chemical & Physical Properties
[ Density]:
1.207 g/cm3
[ Boiling Point ]:
494ºC at 760 mmHg
[ Melting Point ]:
260-265 °C (dec.)(lit.)
[ Molecular Formula ]:
C4H8N2O2
[ Molecular Weight ]:
116.11900
[ Flash Point ]:
252.6ºC
[ Exact Mass ]:
116.05900
[ PSA ]:
86.18000
[ LogP ]:
0.13780
[ Vapour Pressure ]:
6.7E-10mmHg at 25°C
[ Index of Refraction ]:
1.488
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H317
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R43
[ Safety Phrases ]:
S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2924199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Bioorg. Med. Chem. 17 , 5414-9, (2009)
Fumarate, a four-carbon trans dicarboxylic acid, is the allosteric activator of the human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME). In this paper, we discuss the effects of the str...
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core.Bioorg. Med. Chem. Lett. 14 , 377, (2004)
A novel series of piperazines appended to a succinamide backbone were synthesized and found to have a high affinity for the melanocortin-4 receptor (IC(50)s ranging from <0.1 to 200 nM). Both agonists...
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.Biochemistry 43(30) , 9866-76, (2004)
Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions, but more potent and selective agents should improve on the therapeutic index of currently used drugs. In a...