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2-Aminopurine-9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside

Names

[ CAS No. ]:
109304-04-3

[ Name ]:
2-Aminopurine-9-beta-D-(2'-deoxy-2'-fluoro)arabino-riboside

[Synonym ]:
9-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-9H-purin-2-amine
9H-Purin-2-amine, 9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-

Biological Activity

[Description]:

2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
662.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H12FN5O3

[ Molecular Weight ]:
269.23

[ Flash Point ]:
354.7±34.3 °C

[ Exact Mass ]:
269.092407

[ LogP ]:
-0.70

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.834

Related Compounds