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TD-0212

Names

[ CAS No. ]:
1073549-10-6

[ Name ]:
TD-0212

Biological Activity

[Description]:

TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin

[Target]

pKi: 8.9 (AT1) pIC50: 9.2 (NEP)[1].


[References]

[1]. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34FN3O4S

[ Molecular Weight ]:
527.65

Related Compounds