12-hydroxyoctadecanoic acid
Names
[ CAS No. ]:
106-14-9
[ Name ]:
12-hydroxyoctadecanoic acid
[Synonym ]:
MFCD00004592
DL-12-hydroxystearic acid
Octadecanoic acid, 12-hydroxy-
EINECS 203-366-1
UNII:933ANU3H2S
12-Hydroxyoctadecanoic acid
DL-12-hydroxy stearic acid
12-Hydroxystearic acid
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
436.3±18.0 °C at 760 mmHg
[ Melting Point ]:
80-81ºC
[ Molecular Formula ]:
C18H36O3
[ Molecular Weight ]:
300.477
[ Flash Point ]:
231.8±17.7 °C
[ Exact Mass ]:
300.266449
[ PSA ]:
57.53000
[ LogP ]:
6.03
[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C
[ Index of Refraction ]:
1.468
[ Storage condition ]:
−20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WI3850000
- CHEMICAL NAME :
- Stearic acid, 12-hydroxy-
- CAS REGISTRY NUMBER :
- 106-14-9
- BEILSTEIN REFERENCE NO. :
- 1726730
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H36-O3
- MOLECULAR WEIGHT :
- 300.54
- WISWESSER LINE NOTATION :
- QV10YQ6
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg/40W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 700 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,87,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1187 No. of Facilities: 5682 (estimated) No. of Industries: 85 No. of Occupations: 50 No. of Employees: 71848 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1187 No. of Facilities: 5607 (estimated) No. of Industries: 44 No. of Occupations: 38 No. of Employees: 52609 (estimated) No. of Female Employees: 4374 (estimated)
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
WI3850000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918199090
[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Int. J. Pharm. 486 , 77-87, (2015)
The aim of this work is to study the digestibility of PEG-30-di-(polyhydroxystearate) (Cithrol(®) DPHS) and its semisolid novel self-nanoemulsifying drug delivery systems (SNEDDS). Furthermore, the SN...
Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma.Int. J. Pharm. 495 , 972-80, (2015)
In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modif...
Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect.Int. J. Pharm. 484(1-2) , 163-71, (2015)
The present paper attempted to develop temperature-sensitive and core-shell structured gel-nanocarriers (gel-NCs) for paclitaxel (PTX) with 12-hydroxystearic acid (12-HSA) as an organic gelator, which...