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Tr-PEG2-OH

Names

[ CAS No. ]:
105589-77-3

[ Name ]:
Tr-PEG2-OH

[Synonym ]:
diethylene glycol monotrityl ether
diethylene glycol monotritylate
7,7,7-triphenyl-2,5-dioxaheptan-1-ol
monotritylated diethylene glycol
7,7,7-Triphenyl-3,6-dioxaheptanol

Biological Activity

[Description]:

Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24O3

[ Molecular Weight ]:
348.43500

[ Exact Mass ]:
348.17300

[ PSA ]:
38.69000

[ LogP ]:
4.00400

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds