Propargyl-PEG2-OH

Names

[ Name ]:
Propargyl-PEG2-OH

[Synonym ]:
HUSDTFBXUYBZJD-UHFFFAOYSA
2-[2-(2-Propyn-1-yloxy)ethoxy]ethanol
2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL
Propargyl-PEG3
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol
Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-
propargyl-PEG2-OH
Ethanol,2-(2-(2-propynyloxy)ethoxy)
3,6-dioxanon-8-yn-1-ol
ethanol, 2-(2-(2-propynyloxy)ethoxy)-
2,6-DIMETHYLCYCLOHEXANOL
O-Prop-2-inyl-diaethylenglykol
2-(2-Prop-2-inyloxy-aethoxy)-aethanol
2-(2-prop-2-ynyloxy-ethoxy)-ethanol

Biological Activity

[Description]:

Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.6±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₂O₃

[ Molecular Weight ]:
144.168

[ Flash Point ]:
90.3±21.8 °C

[ Exact Mass ]:
144.078644

[ PSA ]:
38.69000

[ LogP ]:
-0.61

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.453

Propargyl-PEG2-OH

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds