Thiol-C2-PEG2-OH

Names

[ CAS No. ]:
56282-36-1

[ Name ]:
Thiol-C2-PEG2-OH

[Synonym ]:
2-[2-(2-sulfanylethoxy)ethoxy]ethanol

Biological Activity

[Description]:

Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.094g/cm3

[ Boiling Point ]:
270.3ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₄O₃S

[ Molecular Weight ]:
166.23900

[ Flash Point ]:
117.3ºC

[ Exact Mass ]:
166.06600

[ PSA ]:
77.49000

[ Index of Refraction ]:
1.475

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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