4-Methylanisole
Names
[ CAS No. ]:
104-93-8
[ Name ]:
4-Methylanisole
[Synonym ]:
1-Methoxy-4-methylbenzene
p-Methoxytoluene
MFCD00008413
4-Methylanisole
Benzene, 1-methoxy-4-methyl-
p-Cresol Methyl Ether
4-Methoxytoluene
EINECS 203-253-7
Methyl 4-methylphenyl ether
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
0.96
[ Boiling Point ]:
174 ºC
[ Melting Point ]:
-32°C
[ Molecular Formula ]:
C8H10O
[ Molecular Weight ]:
122.164
[ Flash Point ]:
53 ºC
[ Exact Mass ]:
122.073166
[ PSA ]:
9.23000
[ LogP ]:
2.59
[ Vapour Pressure ]:
1.7±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.494
[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Combustible.
[ Water Solubility ]:
slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BZ8780000
- CHEMICAL NAME :
- Anisole, p-methyl-
- CAS REGISTRY NUMBER :
- 104-93-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H10-O
- MOLECULAR WEIGHT :
- 122.18
- WISWESSER LINE NOTATION :
- 1OR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1920 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,214,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3360 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,393,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83207 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 207 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83207 No. of Facilities: 1443 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 13288 (estimated) No. of Female Employees: 9258 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H302-H315-H361-H412
[ Precautionary Statements ]:
P273-P281
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R10;R22
[ Safety Phrases ]:
S36/37-S16
[ RIDADR ]:
UN 1993 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
BZ8780000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
29093090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909309090
[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Phytochemistry 109 , 66-75, (2014)
Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surp...
Developmental immunotoxicity testing of 4-methyl anisole.Regul Toxicol Pharmacol 72 , 379-85, (2015)
The developmental immunotoxicity of 4-methyl anisole (4MA) was investigated in the rat. Four study designs were used, with either premating or post-weaning onset of exposure, continued to postnatal da...
Individual solvent/solute interactions through social isomerism.J. Am. Chem. Soc. 125(46) , 13981-3, (2003)
Reversible coencapsulation of a solute molecule and a single solvent molecule takes place in solution at ambient temperature. Two isomeric complexes are formed (social isomers), and their relative ene...