3-APPA(CGP 27492)(mM/ml)
Names
[ CAS No. ]:
103680-47-3
[ Name ]:
3-APPA(CGP 27492)(mM/ml)
[Synonym ]:
3-Aminopropanephosphinic acid
3-amnopropylphosphonous acid
3-Aminopropylphosphonous acid
Cgp 27 492
Biological Activity
[Description]:
3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of GABA, is a GABAB receptor agonist[1].
[Related Catalog]:
[In Vitro]
3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC50=1.84 + 0.23 μM), but does not produce an initial contraction[2].
[In Vivo]
3-Aminopropylphosphinic acid (5 mg/kg; iv) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs[3]. Animal Model: guinea pigs[3] Dosage: 5 mg/kg Administration: IV Result: Blocked the inhibitory effects of GABA against vagal broncho-spasm.
[References]
[1]. [1]Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9.
[2]. [2]Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6.
[3]. [3]Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24.
Chemical & Physical Properties
[ Molecular Formula ]:
C3H10NO2P
[ Molecular Weight ]:
123.09
[ Exact Mass ]:
122.03700
[ PSA ]:
95.92000
[ Vapour Pressure ]:
0.001mmHg at 25°C
Synthetic Route
Precursor & DownStream
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