GSK 2018682

Names

[ Name ]:
GSK 2018682

[Synonym ]:
CPD1224
GSK2018682

Biological Activity

[Description]:

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Inflammation/Immunology

[Target]

pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor)[1]

[In Vitro]

GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1].

[References]

[1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.

[Related Small Molecules]

Ki16425 | Siponimod | AM966 | Ozanimod | BMS-986020 | LPA2 antagonist 1 | TY-52156 | AM095 | Etrasimod | ACT-334441 | Ponesimod | Amiselimod hydrochloride | S1p receptor agonist 1 | ONO-7300243

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁ClN₄O₄

[ Molecular Weight ]:
440.88

[ Storage condition ]:
2-8℃

Related Compounds

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