Ki16425

Names

[ Name ]:
Ki16425

[Synonym ]:
S1315_Selleck
Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-
3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid
3-({4-[4-({[1-(2-Chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]benzyl}sulfanyl)propanoic acid
cc-102
Ki16425

Biological Activity

[Description]:

Ki16425 is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Cancer

[References]

[1]. Ohta H, et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.Mol Pharmacol, 2003, 64(4), 994-1005.

[2]. Moughal NA, et al. Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. J Neurochem, 2006, 98(6), 1920-1929.

[3]. Ma L, et al. Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. J Neurochem, 2009, 109(2), 603-610.

[Related Small Molecules]

Siponimod | AM966 | Ozanimod | BMS-986020 | LPA2 antagonist 1 | TY-52156 | AM095 | Etrasimod | ACT-334441 | Ponesimod | Amiselimod hydrochloride | S1p receptor agonist 1 | ONO-7300243 | (S) FTY720 Phosphate

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
623.7±55.0 °C at 760 mmHg

[ Melting Point ]:
59.5-60.5 °C

[ Molecular Formula ]:
C₂₃H₂₃ClN₂O₅S

[ Molecular Weight ]:
474.957

[ Flash Point ]:
331.0±31.5 °C

[ Exact Mass ]:
474.101624

[ PSA ]:
126.96000

[ LogP ]:
4.63

[ Appearance of Characters ]:
solid | white

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 16 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells.

PLoS ONE 10(3) , e0122060, (2015)

Lysophosphatidic acid (LPA) is a multi-function glycerophospholipid. LPA affects the proliferation of hepatocytes and stellate cells in vitro, and in a partial hepatectomy induced liver regeneration m...

Related Compounds

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