BMS-986020

Names

[ Name ]:
BMS-986020

[Synonym ]:
1-{4'-[3-Methyl-4-({[(1R)-1-phenylethoxy]carbonyl}amino)-1,2-oxazol-5-yl]-4-biphenylyl}cyclopropanecarboxylic acid
Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-

Biological Activity

[Description]:

BMS-986020 is an LPA1 antagonist.target: LPA1BMS-986020 is in Phase 2 clinical development for treating idiopathic pulmonary fibrosis. BMS-986020 selectively inhibits the LPA receptor, which is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions, such as cell proliferation, platelet aggregation, smooth muscle contraction and others.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Cancer

[References]

[1]. Kihara Y et al. Lysophospholipid receptors in drug discovery. Exp Cell Res. 2015 May 1;333(2):171-7.

[Related Small Molecules]

Ki16425 | Siponimod | AM966 | Ozanimod | LPA2 antagonist 1 | TY-52156 | AM095 | Etrasimod | ACT-334441 | Ponesimod | Amiselimod hydrochloride | S1p receptor agonist 1 | ONO-7300243 | (S) FTY720 Phosphate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
664.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₂₆N₂O₅

[ Molecular Weight ]:
482.527

[ Flash Point ]:
355.9±31.5 °C

[ Exact Mass ]:
482.184174

[ LogP ]:
4.99

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.647

[ Storage condition ]:
2-8℃

Related Compounds

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