Phenserine
Names
[ CAS No. ]:
101246-66-6
[ Name ]:
Phenserine
Biological Activity
[Description]:
[Related Catalog]:
[Target]
AChE; β-amyloid precursor protein; β-amyloid peptide[1]
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.228g/cm3
[ Boiling Point ]:
468.7ºC at 760mmHg
[ Molecular Formula ]:
C20H23N3O2
[ Molecular Weight ]:
337.41600
[ Flash Point ]:
237.3ºC
[ Exact Mass ]:
337.17900
[ PSA ]:
44.81000
[ LogP ]:
3.74250
[ Vapour Pressure ]:
5.85E-09mmHg at 25°C
[ Index of Refraction ]:
1.633
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY8586000
- CHEMICAL NAME :
- Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, phenylcarbamate (ester), (3aS-cis)-
- CAS REGISTRY NUMBER :
- 101246-66-6
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H23-N3-O2
- MOLECULAR WEIGHT :
- 337.46
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5409948
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UY8586000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Ann. Neurol. 75(5) , 684-99, (2014)
Proteolytic cleavage of the amyloid precursor protein (APP) generates β-amyloid (Aβ) peptides. Prolonged accumulation of Aβ in the brain underlies the pathogenesis of Alzheimer disease (AD) and is reg...