Amastatin · HCl

Names

[ Name ]:
Amastatin · HCl

[Synonym ]:
amastatin hydrochloride
MFCD00150636
Aspartic acid, N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)valylvalyl-, hydrochloride (1:1)
N-(3-Amino-2-hydroxy-5-methylhexanoyl)valylvalylaspartic acid hydrochloride (1:1)

Biological Activity

[Description]:

Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Amastatin hydrochloride (1-10000 ng/ml) exhibitcd inhibitory profiles of E. cuniczcli replication in vitro in a dose dependent manner[2].

[References]

[1]. S H Wilkes, et al. The Slow, Tight Binding of Bestatin and Amastatin to Aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62.

[2]. J J Millership, et al. In Vitro and in Vivo Evaluation of Aminopeptidase Inhibitors as Antimicrosporidial Therapies. J Eukaryot Microbiol. 2001;Suppl:95S-98S.

Chemical & Physical Properties

[ Boiling Point ]:
795.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₉ClN₄O₈

[ Molecular Weight ]:
511.009

[ Flash Point ]:
434.7ºC

[ Exact Mass ]:
510.245636

[ PSA ]:
208.15000

[ LogP ]:
1.72140

[ Vapour Pressure ]:
3.14E-29mmHg at 25°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Zollner, H.

Handbook of Enzyme Inhibitors 2nd ed.,, (1993) 2nd Ed. , 547

Beynon, R.J. and Bond, J.S.

Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 247

Related Compounds

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