100938-10-1

100938-10-1 structure

Name: Amastatin · HCl
Chemical Name: Amastatin hydrochloride hydrate
CAS Number: 100938-10-1
Molecular Formula: C₂₁H₃₉ClN₄O₈
Molecular Weight: 511.009
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-08-28 13:38:05
Modify Date: 2024-01-02 06:54:15
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1].

Name	Amastatin hydrochloride hydrate
Synonyms	amastatin hydrochloride MFCD00150636 Aspartic acid, N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)valylvalyl-, hydrochloride (1:1) N-(3-Amino-2-hydroxy-5-methylhexanoyl)valylvalylaspartic acid hydrochloride (1:1)

Description	Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Amastatin hydrochloride (1-10000 ng/ml) exhibitcd inhibitory profiles of E. cuniczcli replication in vitro in a dose dependent manner[2].
References	[1]. S H Wilkes, et al. The Slow, Tight Binding of Bestatin and Amastatin to Aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62. [2]. J J Millership, et al. In Vitro and in Vivo Evaluation of Aminopeptidase Inhibitors as Antimicrosporidial Therapies. J Eukaryot Microbiol. 2001;Suppl:95S-98S.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport