D-3263 (hydrochloride)

Names

[ Name ]:
D-3263 (hydrochloride)

[Synonym ]:
2H-Benzimidazol-2-one, 3-(2-aminoethyl)-1,3-dihydro-5-methoxy-1-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]carbonyl]-, hydrochloride (1:1)
3-(2-Aminoethyl)-1-{[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]carbonyl}-5-methoxy-1,3-dihydro-2H-benzimidazol-2-one hydrochloride (1:1)
D-3263 HCl
D-3263 (hydrochloride)

Biological Activity

[Description]:

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

[In Vitro]

D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH[1].

[References]

[1]. enteric-coated TRPM8 agonist D-3263 hydrochloride

[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | GSK-1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG-517 | SB-366791 | IcilinAG-3-5

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₂ClN₃O₃

[ Molecular Weight ]:
409.950

[ Exact Mass ]:
409.213226

[ Storage condition ]:
2-8℃

Related Compounds

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