(+/-)-2-HYDROXYTRIDECANOICACID

Names

[ Name ]:
(+/-)-2-HYDROXYTRIDECANOICACID

[Synonym ]:
3-2-Cpp
DL-CPP

Biological Activity

[Description]:

(RS)-CPP ((±)-CPP) is a potent and selective NMDA antagonist. (RS)-CPP inhibits central neuron responses, and has anticonvulsant activity[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. J Davies, et al. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Res. 1986 Sep 10;382(1):169-73.

Chemical & Physical Properties

[ Density]:
1.408g/cm3

[ Boiling Point ]:
546.7ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₇N₂O₅P

[ Molecular Weight ]:
252.20

[ Flash Point ]:
284.4ºC

[ Exact Mass ]:
252.08800

[ PSA ]:
119.91000

[ Vapour Pressure ]:
2.14E-13mmHg at 25°C

[ Index of Refraction ]:
1.53

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity.

Toxicol. In Vitro 29 , 1916-31, (2015)

Testing hepatotoxicity is a crucial step in the development and toxicological assessment of drugs and chemicals. Bio-activation can lead to the formation of metabolites which may present toxicity for ...

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.

PLoS ONE 9(11) , e112413, (2014)

Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Geneti...

Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.

Proc. Natl. Acad. Sci. U. S. A. 112 , 6712-7, (2015)

Dynamic changes in synaptic strength are thought to be critical for higher brain function such as learning and memory. Alterations in synaptic strength can result from modulation of AMPA receptor (AMP...