Icapamespib

Names

[ Name ]:
Icapamespib

Biological Activity

[Description]:

Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5 nM. Icapamespib is able to cross blood-brain barrier[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

Research Areas >> Neurological Disease

[References]

[1]. Bolaender A, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12(1):4669. Published 2021 Aug 3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃IN₆O₂S

[ Molecular Weight ]:
526.39

[ Exact Mass ]:
526.06500

[ PSA ]:
125.41000

[ LogP ]:
4.50080

Related Compounds

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