Piperine from black pepper inhibits activation-induced proliferation and effector function of T lymphocytes.
Carolyn D Doucette, Gemma Rodgers, Robert S Liwski, David W Hoskin
Index: J. Cell. Biochem. 116 , 2577-88, (2015)
Full Text: HTML
Abstract
Piperine is a major alkaloid component of black pepper (Piper nigrum Linn), which is a widely consumed spice. Here, we investigated the effect of piperine on mouse T lymphocyte activation. Piperine inhibited polyclonal and antigen-specific T lymphocyte proliferation without affecting cell viability. Piperine also suppressed T lymphocyte entry into the S and G2 /M phases of the cell cycle, and decreased expression of G1 -associated cyclin D3, CDK4, and CDK6. In addition, piperine inhibited CD25 expression, synthesis of interferon-γ, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells. The inhibitory effect of piperine on T lymphocytes was associated with hypophosphorylation of Akt, extracellular signal-regulated kinase, and inhibitor of κBα, but not ZAP-70. The ability of piperine to inhibit several key signaling pathways involved in T lymphocyte activation and the acquisition of effector function suggests that piperine might be useful in the management of T lymphocyte-mediated autoimmune and chronic inflammatory disorders.© 2015 Wiley Periodicals, Inc.
Related Compounds
Related Articles:
2014-10-17
[Int. J. Food Microbiol. 189 , 98-105, (2014)]
2014-01-01
[PLoS ONE 9(6) , e99421, (2014)]
2014-04-01
[Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)]
Glucose recognition proteins for glucose sensing at physiological concentrations and temperatures.
2014-07-18
[ACS Chem. Biol. 9(7) , 1595-602, (2014)]
Reservoirs of listeria species in three environmental ecosystems.
2014-09-01
[Appl. Environ. Microbiol. 80(18) , 5583-92, (2014)]