Synthesis of novel imidazole-containing DNA minor groove binding oligopeptides related to the antiviral antibiotic netropsin
K Krowicki, JW Lown
Index: Krowicki, Krzysztof; Lown, J. William Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3493 - 3501
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Citation Number: 75
Abstract
Analysis of the structural and stereochemical requirements for the strict DNA base sequence recognition of (AT), and (AT), respectively for the oligopeptide minor groove binding agents netropsin and distamycin leads to proposals for the rational structure modification for altered base and sequence recognition. The syntheses of new analogues of the natural oligopeptide antiviral antibiotic netropsin bearing one or more imidazole moieties in place ...
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