The Journal of Organic Chemistry

Efficient total syntheses of the oligopeptide antibiotics netropsin and distamycin

JW Lown, K Krowicki

Index: Lown, J. William; Krowicki, Krzysztof Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3774 - 3779

Full Text: HTML

Citation Number: 106

Abstract

New and efficient total syntheses of the natural oligopeptide antiviral antibiotics netropsin and distamycin are described. These procedures feature a different strategy of introduction of the terminal groups from that used hitherto, high yield coupling steps, improvements in the Pinner reaction for introducing the amidine moiety, and the novel use of N-formylimidazole for introduction of the formyl moiety in distamycin. The methods also avoid column ...