Synthetic studies on antitumor antibiotic, bleomycin. 27. Man-designed bleomycin with altered sequence specificity in DNA cleavage

…, M Ohno, T Shiraki, Y Sugiura, K Maeda

Index: Otsuka; Masuda; Haupt; Ohno; Shiraki; Sugiura; Maeda Journal of the American Chemical Society, 1990 , vol. 112, # 2 p. 838 - 845

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Citation Number: 99

Abstract

Abstract: The synthetic approach to the concerted antitumor mechanism of bleomycin is studied by introducing a dynamic change into the 02-activation moiety and DNA-binding site. A model PYML (6)-bleomycin previously reported, possessing an oxygen-activating methoxypyridine moiety and a DNA-binding bithiazole moiety, exhibits a nucleotide cleavage mode virtually identical with that of bleomycin. Herein reported is a newly ...