Antitumor agents. 177 1. Design, syntheses, and biological evaluation of novel etoposide analogs bearing pyrrolecarboxamidino group as DNA topoisomerase II …
Z Ji, HK Wang, KF Bastow, XK Zhu, SJ Cho…
Index: Ji, Zheng; Wang, Hui-Kang; Bastow, Kenneth F.; Zhu, Xiao-Kang; Cho, Sung Jin; Cheng, Yung-Chi; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 607 - 612
Full Text: HTML
Citation Number: 29
Abstract
Novel water-soluble 4β-amino-4′-O-demethylepipodophyllotoxin derivatives (6–12), designed to enhance minor groove binding ability, were synthesized and screened against NCI's in vitro disease-oriented human tumor cells. Among them, 4′-O-demethyl-4β-[N-(1‴- methyl-4‴-nitro-pyrrole-2‴-carbonyl)-4 ″-aminoanilino]-4-desoxypodophyllotoxin (10) and its HCl salt (11) were found to exhibit potent cytotoxic activities (average log GI50=− 6.91,− ...
Related Articles:
[Otsuka; Masuda; Haupt; Ohno; Shiraki; Sugiura; Maeda Journal of the American Chemical Society, 1990 , vol. 112, # 2 p. 838 - 845]
Efficient total syntheses of the oligopeptide antibiotics netropsin and distamycin
[Lown, J. William; Krowicki, Krzysztof Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3774 - 3779]
[Krowicki, Krzysztof; Lown, J. William Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3493 - 3501]