Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer

JA Heyes, D Niculescu-Duvaz, RG Cooper…

Index: Journal of Medicinal Chemistry, , vol. 45, # 1 p. 99 - 114

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Citation Number: 166

Abstract

... Journal of Medicinal Chemistry. ... The lipids were assayed in vitro for their ability to transfect cells with the lacZ gene. Chemical Syntheses. Diether Lipids. The diether lipids were synthesized via the synthetic route displayed in Figure 1. The chemistry of Carruthers et al. ...

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