Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABA B receptor affinities

NI Carruthers, JM Spitler, SC Wong, DJ Blythin…

Index: Carruthers, Nicholas I.; Spitler, James M.; Wong, Shing-Chun; Blythin, David J.; Chen, Xiao; Shue, Ho-Jane; She, Hoyan S.; Lee, Joe F.; Rizzo, Charles; Ting, Pauline C.; West Jr., Robert E. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3059 - 3064

Full Text: HTML

Citation Number: 11

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of γ-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABA B receptor investigated. ... Compounds containing a chiral center were prepared as mixtures of ...