Synlett

Highly Regioselective and Efficient Synthesis of Aminoepoxides by Ring Closure of Aminohalohydrins Mediated by KF-Celite

…, P Hoyos, JV Sinisterra, AR Alcántara, W Holzer

Index: Pace, Vittorio; Hoyos, Pilar; Sinisterra, Jose Vicente; Alcantara, Andres R.; Holzer, Wolfgang Synlett, 2011 , # 13 p. 1831 - 1834

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Citation Number: 2

Abstract

Abstract The regioselective synthesis of several aminoepoxides has been achieved without observing any trace of azetidinols, which are usually reported as the exclusive reaction products when aminohalohydrins are treated with bases. The use of the mild supported base KF-Celite in refluxing acetonitrile is crucial for modulating the excellent regioselectivity observed.