Fischer indole synthesis in brønsted acidic ionic liquids: a green, mild, and regiospecific reaction system
…, WL Yang, SP Luo, BT Wang, J Wu…
Index: Xu, Dan-Qian; Yang, Wen-Long; Luo, Shu-Ping; Wang, Bing-Tao; Wu, Jian; Xu, Zhen-Yuan European Journal of Organic Chemistry, 2007 , # 6 p. 1007 - 1012
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Citation Number: 56
Abstract
Abstract A novel one-pot Fischer indole synthesis approach has been developed by using Brønsted acidic ionic liquids as dual solvent-catalysts. Yields of 83–97% were obtained after reaction in BMImHSO 4 at 70–110 C in 0.5–6 h, and exclusive formation of 2, 3-disubstituted indoles was observed in the reaction of alkyl methyl unsymmetrical ketones. The indoles produced could be conveniently separated from the reaction mixture without any volatile ...
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