AP 24149

Modify Date: 2023-06-12 15:35:15

AP 24149 structure	Common Name	AP 24149
	CAS Number	926922-29-4	Molecular Weight	417.44300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₄N₅OP	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AP 24149

AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

Name	9-[(E)-2-(2,6-Dimethylphenyl)vinyl]-N-[4-(dimethylphosphoryl)phen yl]-9H-purin-6-amine

Description	AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
Target	Abl:3.6 nM (IC50) Src:9.1 nM (IC50)
References	[1]. Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28.

Molecular Formula	C₂₃H₂₄N₅OP
Molecular Weight	417.44300
Exact Mass	417.17200
PSA	82.51000
LogP	5.13560

N/A

CAS#:926922-15-8

AP 24149

CAS#:926922-29-4

Literature: Wang, Yihan; Shakespeare, William C.; Huang, Wei-Sheng; Sundaramoorthi, Raji; Lentini, Scott; Das, Sasmita; Liu, Shuangying; Banda, Geeta; Wen, David; Zhu, Xiaotian; Xu, Qihong; Keats, Jeffrey; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T.; Broudy, Mark I.; Russian, Karin; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4907 - 4912

AP 24149

Use of AP 24149

Names

AP 24149 Biological Activity

Chemical & Physical Properties

Synthetic Route