2196197-89-2
2196197-89-2 structure
- Name: AP-202
- Chemical Name: AP-202
- CAS Number: 2196197-89-2
- Molecular Formula: C11H16N4
- Molecular Weight: 204.277
- Create Date: 2022-07-02 10:45:26
- Modify Date: 2024-04-05 06:22:37
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AP-202 (AP202) is a highly potent and selective α4β2 nAChR antagonist with binding Ki of 18 nM, 57-fold selectivity over α3β4 receptor.AP-202 is agonist activity, also dispalys 40-fold, 10-fold and 90-fold selectivity over α4β4, α3β2, α3β4α5 receptors, does not activate α7 nAChR or block acetylcholine induced changes in membrane potential.AP-202 showed significant activity in blocking nicotine priming-induced as well as cue-induced reinstatement of nicotine seeking in vivo.
| Name | AP-202 |
|---|
| Description | AP-202 (AP202) is a highly potent and selective α4β2 nAChR antagonist with binding Ki of 18 nM, 57-fold selectivity over α3β4 receptor.AP-202 is agonist activity, also dispalys 40-fold, 10-fold and 90-fold selectivity over α4β4, α3β2, α3β4α5 receptors, does not activate α7 nAChR or block acetylcholine induced changes in membrane potential.AP-202 showed significant activity in blocking nicotine priming-induced as well as cue-induced reinstatement of nicotine seeking in vivo. |
|---|---|
| References | 1. Jinhua Wu, et al. J Med Chem. 2017 Dec 28;60(24):10092-10104. |
| Molecular Formula | C11H16N4 |
|---|---|
| Molecular Weight | 204.277 |