AP 24149

Names

[ CAS No. ]:
926922-29-4

[ Name ]:
AP 24149

Biological Activity

[Description]:

AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[Target]

Abl:3.6 nM (IC50)

Src:9.1 nM (IC50)

[References]

[1]. Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₄N₅OP

[ Molecular Weight ]:
417.44300

[ Exact Mass ]:
417.17200

[ PSA ]:
82.51000

[ LogP ]:
5.13560

Synthetic Route

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Related Compounds