WAY-181187 hydrochloride

Modify Date: 2024-09-14 18:11:28

WAY-181187 hydrochloride structure	Common Name	WAY-181187 hydrochloride
	CAS Number	554403-08-6	Molecular Weight	417.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₄Cl₂N₄O₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WAY-181187 hydrochloride

WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

Name	2-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylindol-3-yl]ethanamine,hydrochloride
Synonym	More Synonyms

Description	WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT6 Receptor:2.2 nM (Ki) 5-HT6 Receptor:6.6 nM (EC50)
References	[1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.

Molecular Formula	C₁₅H₁₄Cl₂N₄O₂S₂
Molecular Weight	417.33
Exact Mass	415.99400
PSA	119.01000
LogP	5.32520

unii-xgk56c5380

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

WAY-181187 hydrochloride

Use of WAY-181187 hydrochloride

Names

WAY-181187 hydrochloride Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.